HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-(4-hydroxyphenoxy)-2-methylpropanoate → 2-Methyl-2-[4-(5-methyl-2-phenyloxazol-4-ylmethoxy)phenoxy]propionic Acid, Ethyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-(4-hydroxyphenoxy)-2-methylpropanoate | HCID 181741 | — |
| Reactant | 4-(Hydroxymethyl)-5-methyl-2-phenyl-1,3-oxazole | HCID 11571932 | — |
| Product | 2-Methyl-2-[4-(5-methyl-2-phenyloxazol-4-ylmethoxy)phenoxy]propionic Acid, Ethyl Ester | HCID 23590012 | — |
Reaction Steps
Made from (5-methyl-2-phenyloxazol-4-yl)methanol [Overman, et al., J. Org. Chem. (1979), 44(13), 2323-25] and ethyl 2-(4-hydroxyphenoxy)-2-methylpropanoate (American Home Products, U.S. Pat. No. 3,795,691) via an analogous procedure to that reported for Example 2, Step A: 1H NMR (300 MHz, CDCl3) δ 8.03-8.09 (m, 2H), 7.45-7.52 (m, 3H), 6.94 (d, 2H), 6.88 (d, 2H), 4.99 (s, 2H), 4.37 (q, 2H), 2.47 (s, 3H), 1.60 (s, 6H), 1.33 (t, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07351728B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-64da12dbefc04005be2cb9fa44e754b1 |
| Source note | uspto-grants-2008_04 |