Sodium Hydroxide → (2-Chloro-4-trifluoromethyl-phenoxy)-acetic acid

HRID 898517Notes

Reaction equation

HRID 898517 reaction equation
[OH-].[Na+].[Cl:3][C:4]1[CH:16]=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:14]=[CH:13][C:5]=1[O:6][CH2:7][C:8]([O:10]CC)=[O:9]>CCO>[Cl:3][C:4]1[CH:16]=[C:15]([C:17]([F:18])([F:20])[F:19])[CH:14]=[CH:13][C:5]=1[O:6][CH2:7][C:8]([OH:10])=[O:9]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69403668Ethyl 2-[2-chloro-4-(trifluoromethyl)-phenoxy]acetate

Product 1

HCID 59691547(2-Chloro-4-trifluoromethyl-phenoxy)-acetic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

84 mL of 2 M aqueous NaOH was added to a solution of 23.97 g (0.084 mol) of ethyl (2-chloro-4-trifluoromethyl-phenoxy)-acetate in 200 mL EtOH and the mixture was refluxed for 1 hour. EtOH was concentrated by evaporation i. vac., the residue was diluted with ice water and acidified with 2 M aqueous HCl. The precipitate formed was filtered off, washed with water and dried at 70° C. i. vac.

Workup

  1. temperaturethe mixture was refluxed for 1 hour
  2. concentrationEtOH was concentrated by evaporation i
  3. addition, the residue was diluted with ice water
  4. customThe precipitate formed
  5. filtrationwas filtered off
  6. washwashed with water
  7. customdried at 70° C. i

Sources & evidence

ORD record
ord-10d7652b2e644947bf1ef8ec0cc503c1
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

Loading…