HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Hydroxy-5-nitrobenzonitrile → 5-Amino-2-hydroxybenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Hydroxy-5-nitrobenzonitrile | HCID 11116377 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-Amino-2-hydroxybenzonitrile | HCID 817719 | — |
Reaction Steps
4.50 g (27.00 mmol) of 2-hydroxy-5-nitro-benzonitrile was added to a suspension of 0.45 g Pd/C (10%) in 45 mL EtOAc and the mixture was hydrogenated for 1.5 hours under 3 bar H2atmosphere. The catalyst was filtered off and the residue dried i. vac.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07351719B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-826aa6b6a806481f8e8f446770a26329 |
| Source note | uspto-grants-2008_04 |