HCID 11391343, compound → HCID 11148957, compound

HRID 898529Notes

Reaction equation

HRID 898529 reaction equation
[CH2:1]([N:3]([CH2:18][CH3:19])[CH2:4][CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([N+:15]([O-])=O)=[CH:12][CH:13]=2)[CH:8]=[CH:7]1)[CH3:2]>CO.[Ni]>[CH2:18]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([NH2:15])=[CH:12][CH:13]=2)[CH:8]=[CH:7]1)[CH3:19]

Participants

4

Reactant 1

HCID 11391343HCID 11391343, compound

Product 1

HCID 11148957HCID 11148957, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

650 mg (2.487 mmol) of diethyl-[2-(5-nitro-indol-1-yl)-ethyl]-amine was added to a suspension of 200 mg Raney-Ni in 10 mL MeOH and the mixture was hydrogenated for 2 hours at RT under 20 psi H2 atmosphere. The catalyst was filtered off and the filtrate evaporated down i. vac.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate evaporated down i

Sources & evidence

ORD record
ord-5da59f13088644568680fd2373a98a25
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

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