Water → 2-(2-Chloro-4-trifluoromethyl-phenoxy)-n-[4-(2-diethylamino-ethoxy)-3-methoxy-phenyl]-acetamide

Participants

Reaction Conditions

Reaction Steps

171 mg (0.82 mmol) of CDl was added to a solution of 185 mg (0.73 mmol) of (2-chloro-4-trifluoromethyl-phenoxy)-acetic acid (cf intermediate product Z2b) in 5 mL tetrahydrofuran and the reaction mixture was stirred for 30 minutes at 50° C. Then 0.1 mL (0.73 mmol) of triethylamine and 200 mg (0.73 mmol) of 4-(2-diethylamino-ethoxy)-3-methoxy-phenylamine (see intermediate product Z6b) were added and the solution was stirred for 16 hours at RT. The reaction solution was added to water and stirred for 45 minutes at RT. After filtration the residue was dried in the circulating air dryer.

Provenance & Evidence