Sodium Hydroxide → HCID 68876751, compound

HRID 898566Notes

Reaction equation

HRID 898566 reaction equation
[OH-].[Na+].[Cl:3][C:4]1[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:15]=[CH:14][C:5]=1[O:6][CH:7]([CH3:13])[C:8]([O:10]CC)=[O:9]>CCO>[Cl:3][C:4]1[CH:17]=[C:16]([C:18]([F:19])([F:21])[F:20])[CH:15]=[CH:14][C:5]=1[O:6][CH:7]([CH3:13])[C:8]([OH:10])=[O:9]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 68875187HCID 68875187, compound

Product 1

HCID 68876751HCID 68876751, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

50 mL (0.100 mol) of 2 M aqueous NaOH solution was added to a solution of 14.00 g (0.047 mol) of ethyl 2-(2-chloro-4-trifluoromethyl-phenoxy)-propionate in 100 mL EtOH and the mixture was refluxed for 1 hour. EtOH was evaporated off i. vac., the residue was diluted with ice water and acidified with 2 M aqueous HCl. The precipitate formed was filtered off, washed with water and dried at 70° C. i. vac.

Workup

  1. temperaturethe mixture was refluxed for 1 hour
  2. customEtOH was evaporated off i
  3. addition, the residue was diluted with ice water
  4. customThe precipitate formed
  5. filtrationwas filtered off
  6. washwashed with water
  7. customdried at 70° C. i

Sources & evidence

ORD record
ord-128a977be92d4f718e85ecf56567fc47
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

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