HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Chloro-4-nitro-benzyl)-pyrrolidine → 3-Chloro-4-pyrrolidin-1-ylmethyl-phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Chloro-4-nitro-benzyl)-pyrrolidine | HCID 57663236 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Chloro-4-pyrrolidin-1-ylmethyl-phenylamine | HCID 28721827 | — |
Reaction Steps
A suspension of 1.00 g (4.155 mmol) 1-(2-chloro-4-nitro-benzyl)-pyrrolidine (140a) and 100 mg Raney nickel in 30 mL MeOH were hydrogenated at RT and 10 psi. The catalyst was filtered off and the filtrate evaporated down i. vac.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07351719B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-4d2e7e4ba93d4199ad52f7f75f41af8e |
| Source note | uspto-grants-2008_04 |