Acetic Anhydride → HCID 22668555, compound

HRID 898591Notes

Reaction equation

HRID 898591 reaction equation
[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1.[C:16](OC(=O)C)(=[O:18])[CH3:17]>>[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][N:5]([C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1)[C:16](=[O:18])[CH3:17]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 22569398HCID 22569398, compound

Product 1

HCID 22668555HCID 22668555, compound

Procedure

A solution of 50 g (0.239 mol) N,N-dimethyl-N′-(4-nitro-phenyl)-ethane-1,2-diamine in 500 mL acetic anhydride was stirred for 3.5 h at 130° C., then evaporated down i. vac. and neutralised with saturated aqueous sodium bicarbonate. The residue was exhaustively extracted with EtOAc, the combined org. phases were dried over sodium sulphate and evaporated down i. vac.

Workup

  1. customevaporated down i
  2. extractionThe residue was exhaustively extracted with EtOAc
  3. dry with materialphases were dried over sodium sulphate
  4. customevaporated down i

Sources & evidence

ORD record
ord-1a35edbbbf954c07989f707e33881fc2
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

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