N-(4-amino-phenyl)-N-(2-dimethylamino-ethyl)-acetamide → N-{4-[acetyl-(2-dimethylamino-ethyl)-amino]-phenyl}-2-(2-chloro-4-trifluoromethyl-phenoxy)-acetamide

HRID 898593Notes

Reaction equation

HRID 898593 reaction equation
[Cl:1][C:2]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[CH:9][C:3]=1[O:4][CH2:5][C:6]([OH:8])=O.[NH2:17][C:18]1[CH:23]=[CH:22][C:21]([N:24]([CH2:28][CH2:29][N:30]([CH3:32])[CH3:31])[C:25](=[O:27])[CH3:26])=[CH:20][CH:19]=1>>[C:25]([N:24]([CH2:28][CH2:29][N:30]([CH3:31])[CH3:32])[C:21]1[CH:22]=[CH:23][C:18]([NH:17][C:6](=[O:8])[CH2:5][O:4][C:3]2[CH:9]=[CH:10][C:11]([C:13]([F:16])([F:15])[F:14])=[CH:12][C:2]=2[Cl:1])=[CH:19][CH:20]=1)(=[O:27])[CH3:26]

Participants

3

Reactant 2

HCID 22668488N-(4-amino-phenyl)-N-(2-dimethylamino-ethyl)-acetamideHCID 59691547(2-Chloro-4-trifluoromethyl-phenoxy)-acetic acid

Product 1

HCID 59691671N-{4-[acetyl-(2-dimethylamino-ethyl)-amino]-phenyl}-2-(2-chloro-4-trifluoromethyl-phenoxy)-acetamide

Procedure

The product was prepared according to general working method I from (2-chloro-4-trifluoromethyl-phenoxy)-acetic acid (Z2b) and N-(4-amino-phenyl)-N-(2-dimethylamino-ethyl)-acetamide (142b).

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-f1eb0c9cbe304a8c8a5ef8c6729096e1
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

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