反应详情

A solution of 100 mg (0.217 mmol) N-[3-amino-4-(2-diethylamino-ethoxy)-phenyl]-2-(2-chloro-4-trifluoromethyl-phenoxy)-acetamide (Example 160) in 10 mL acetic anhydride was stirred for 3 h at 100° C. and then evaporated down i. vac. The residue was combined with saturated aqueous sodium bicarbonate and exhaustively extracted with EtOAc. The combined org. phases were dried over sodium sulphate, evaporated down i. vac. and the residue was stirred with ether. The precipitate was filtered off, washed with ether and dried in a HV.

1. customevaporated down i
2. extractionexhaustively extracted with EtOAc
3. dry with materialphases were dried over sodium sulphate
4. customevaporated down i
5. filtrationThe precipitate was filtered off
6. washwashed with ether
7. customdried in a HV