2-Chloro-4-(trifluoromethyl)benzonitrile → (2-Chloro-4-(trifluoromethyl)phenyl)methanamine

HRID 898614Notes

Reaction equation

HRID 898614 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]>[Ni].N>[Cl:1][C:2]1[CH:9]=[C:8]([C:10]([F:11])([F:12])[F:13])[CH:7]=[CH:6][C:3]=1[CH2:4][NH2:5]

Participants

4

Reactant 1

HCID 27364762-Chloro-4-(trifluoromethyl)benzonitrile

Product 1

HCID 22337564(2-Chloro-4-(trifluoromethyl)phenyl)methanamine

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 222AmmoniaSolvent

Procedure

A suspension of 1.000 g (4.865 mmol) 2-chloro-4-trifluoromethyl-benzonitrile and 100 mg Raney nickel in conc. methanolic ammonia was hydrogenated for 20 h at RT and 3 bar. The catalyst was filtered off and the filtrate was evaporated down i. vac.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated down i

Sources & evidence

ORD record
ord-369bffa514c541d2813c2284a501fb99
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

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