Tetrahydrofuran → 1-[3-Chloro-4-(2-diethylamino-ethoxy)-phenyl]-3-(2-chloro-4-trifluoromethyl-benzyl)-urea

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Reaction Steps

0.770 g (4.457 mmol) CDT was added at 0° C. to a solution of 0.870 g (4.151 mmol) 2-chloro-4-trifluoromethyl-benzylamine (Example 168a) in 50 mL abs. THF and the mixture was stirred for 1 h at RT. 1.080 g (4.449 mmol) 3-chloro-4-(2-diethylamino-ethoxy)-phenylamine (Z1b) was added and the mixture was refluxed for 5 h. The reaction mixture was evaporated down i. vac. and the residue was taken up in dichloromethane. The org. phase was washed with 15% aqueous potassium carbonate, dried over sodium sulphate and evaporated down i. vac.

Provenance & Evidence