(E)-3-(4'-chlorobiphenyl-4-yl)acrylic Acid → (e)-3-(4'-Chloro-biphenyl-4-yl)-n-[4-(2-dimethylamino-ethyl)-phenyl]-acrylamide

HRID 898621Notes

Reaction equation

HRID 898621 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11](/[CH:14]=[CH:15]/[C:16]([OH:18])=O)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH3:19][N:20]([CH3:30])[CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][C:26]([NH2:29])=[CH:25][CH:24]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11](/[CH:14]=[CH:15]/[C:16]([NH:29][C:26]3[CH:25]=[CH:24][C:23]([CH2:22][CH2:21][N:20]([CH3:19])[CH3:30])=[CH:28][CH:27]=3)=[O:18])=[CH:12][CH:13]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 5957595(E)-3-(4'-chlorobiphenyl-4-yl)acrylic AcidHCID 149398614-(2-Dimethylaminoethyl)aniline

Product 1

HCID 59691610(e)-3-(4'-Chloro-biphenyl-4-yl)-n-[4-(2-dimethylamino-ethyl)-phenyl]-acrylamide

Procedure

Prepared analogously to Example 172 starting from (E)-3-(4′-chloro-biphenyl-4-yl)-acrylic acid and 4-(2-dimethylamino-ethyl)-phenylamine.

Sources & evidence

ORD record
ord-90a1a390fa2644f0ba0bc50e9814c6f6
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

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