4-(Piperidin-1-ylmethyl)aniline → (e)-3-[5-(4-Chloro-phenyl)-pyridin-2-yl]-n-(4-piperidin-1-ylmethyl-phenyl)-acrylamide

HRID 898625Notes

Reaction equation

HRID 898625 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11](/[CH:14]=[CH:15]/[C:16]([OH:18])=O)=[N:12][CH:13]=2)=[CH:4][CH:3]=1.[N:19]1([CH2:25][C:26]2[CH:31]=[CH:30][C:29]([NH2:32])=[CH:28][CH:27]=2)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11](/[CH:14]=[CH:15]/[C:16]([NH:32][C:29]3[CH:28]=[CH:27][C:26]([CH2:25][N:19]4[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]4)=[CH:31][CH:30]=3)=[O:18])=[N:12][CH:13]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 8461504-(Piperidin-1-ylmethyl)anilineHCID 59691634HCID 59691634, compound

Product 1

HCID 59691558(e)-3-[5-(4-Chloro-phenyl)-pyridin-2-yl]-n-(4-piperidin-1-ylmethyl-phenyl)-acrylamide

Procedure

Prepared analogously to Example 143 starting from (E)-3-[5-(4-chloro-phenyl)-pyridin-2-yl]-acrylic acid (Z34b) and 4-piperidin-1-ylmethyl-phenylamine. The crude product was purified by column chromatography (silica gel, dichloromethane/EtOH/conc. aqueous ammonia 50:10:0.1).

Workup

  1. customThe crude product was purified by column chromatography (silica gel, dichloromethane/EtOH/conc. aqueous ammonia 50:10:0.1)

Sources & evidence

ORD record
ord-226e35d7be444ff2b8fac899208dba9c
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

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