反应详情

Prepared analogously to Example 143 starting from (2-chloro-4-trifluoromethyl-phenoxy)-acetic acid (Z2b) and ethyl 5-amino-2-(2-diethylamino-ethoxy)-benzoate. The reaction mixture was evaporated down i. vac. and the residue was dissolved in dichloromethane. The org. phase was washed with water, dried over sodium sulphate and evaporated down i. vac. Purification by column chromatography (Alox, neutral, act. II-III, gradient petroleum ether/EtOAc 70:30→50:50) yielded the product.

1. customThe reaction mixture was evaporated down i
2. dissolutionand the residue was dissolved in dichloromethane
3. washphase was washed with water
4. dry with materialdried over sodium sulphate
5. customevaporated down i
6. customPurification by column chromatography (Alox, neutral, act. II-III, gradient petroleum ether/EtOAc 70:30→50:50)
7. customyielded the product