Hydrochloric Acid → 5-[2-(2-Chloro-4-trifluoromethyl-phenoxy)-acetylamino]-2-(2-diethylamino-ethoxy)-benzoic acid

Participants

Reaction Steps

4.00 mL 1 M aqueous NaOH solution was added to a solution of 1.00 g (1.934 mmol) ethyl 5-[2-(2-chloro-4-trifluoromethyl-phenoxy)-acetylamino]-2-(2-diethylamino-ethoxy)-benzoate in 30 mL EtOH and the mixture was stirred for 3 h at RT. 4.00 mL 1 M aqueous HCl was added and again the mixture was stirred for 1 h. The reaction mixture was evaporated down i. vac., combined with water and the precipitate was filtered off.

Provenance & Evidence