HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-morpholinoaniline → (2R)-1-Chloro-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-morpholinoaniline | HCID 1485330 | — |
| Reactant | (-)-Epichlorohydrin | HCID 2734062 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | (2R)-1-Chloro-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-propanol | HCID 16655948 | 99.3% |
Reaction Steps
3-Fluoro-4-morpholinyl aniline (39 g) is mixed with R-epichlorohydrin (18.5 g), isopropyl alcohol (200 ml) is added and heated for 16 hours at reflux temperature. The solvent is distilled to give 57 gm of N-[3-Chloro-2-(R)-hydroxypropyl]-3-fluoro-4-morpholinyl aniline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07351824B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-6c599987ebf34f2f8798a5509f04c8d8 |
| Source note | uspto-grants-2008_04 |