HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 4-(Benzyloxy)-2-fluorobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Fluoro-4-hydroxybenzonitrile | HCID 2734675 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 4-(Benzyloxy)-2-fluorobenzonitrile | HCID 11333628 | 96% |
Reaction Steps
Following General Procedure F and using 2-fluoro-4-hydroxy-benzonitrile (11.37 g, 83 mmol), acetone (100 mL), potassium carbonate (30 g, 165.8 mmol) followed by benzyl bromide (10.84 mL, 91 mmol) the title product (18 g, 96%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07351737B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-f315321bebd043eab36d8f43e1a4e8e4 |
| Source note | uspto-grants-2008_04 |