反应详情

温度

70 °C

A solution of 4-benzyloxy-2-fluoro-benzyl bromide (Compound 10, 18 g, 58 mmol) in a mixture of ethanol (90 mL) and water (10 mL) was treated with sodium cyanide (4.25 g, 86,8 mmol) and the resulting reaction mixture was heated at 70° C. for 1 h. Potassium hydroxide (6.5 g, 115.7 mmol) was then added and heating was continued for another 5 h. The volatiles were evaporated in vacuo, the residue was diluted with water and neutralized with hydrochloric acid and the precipitated solid was filtered, washed with water and dried to afford the title product as a yellow solid (13 g, 81%).

1. customthe resulting reaction mixture
2. temperatureheating
3. customThe volatiles were evaporated in vacuo
4. additionthe residue was diluted with water and neutralized with hydrochloric acid
5. filtrationthe precipitated solid was filtered
6. washwashed with water
7. customdried