HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 69212794, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 2-Fluoro-4-iodo phenyl acetic acid methyl ester | HCID 18710225 | — |
| Reactant | 6-Ethynyl-8-trimethylsilanylethynyl-2,2,4,4-tetramethyl chroman | HCID 60083888 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | HCID 69212794 | HCID 69212794 | — |
Reaction Steps
Following general procedure J and using 6-ethynyl-8-trimethylsilanylethylnyl-2,2,4,4-tetramethyl chroman (Compound 37, 0.1 g, 0.32 mmol), 2-fluoro-4-iodo phenyl acetic acid methyl ester (see U.S. Pat. No. 6,252,090, 0.095 g, 0.32 mmol), triethyl amine, copper(I)iodide (0.019 g, 0.1 mmol) and dichlorobis(triphenylphosphine)palladium(II) (0.071 g, 0.1 mmol), followed by flash column chromatography over silica gel (230-400 mesh) using 4-10% ethyl acetate in hexane as the eluent, the title compound was obtained as an oil (0.11 g, 72%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07351737B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-52dbb16ca4ca41dda155fbafe905575d |
| Source note | uspto-grants-2008_04 |