HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → [4-(8-Ethynyl-2,2,4,4-tetramethyl-chroman-6-ylethynyl)-2-fluoro-phenyl]-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | HCID 69212794 | HCID 69212794 | — |
| Solvent | Water | HCID 962 | — |
| Product | [4-(8-Ethynyl-2,2,4,4-tetramethyl-chroman-6-ylethynyl)-2-fluoro-phenyl]-acetic acid | HCID 10237512 | — |
Reaction Steps
Following general procedure K and using [2-fluoro-4-(2,2,4,4-tetramethyl-8-trimethylsilanylethynyl-chroman-6-ylethynyl)-phenyl]-acetic acid methyl ester (Compound 39, 0.11 g, 0.23 mmol), methanol, tetrahydrofuran, water and lithium hydroxide monohydrate followed by recrystallization from hot acetonitrile, the title compound was obtained as a pale yellow solid (0.045 g, 50%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07351737B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-41ea9e772268457f92ec3345e86f297e |
| Source note | uspto-grants-2008_04 |