Hydrochloric Acid → HCID 59692077, compound

Participants

Reaction Steps

A solution of ethyl-8-cyano-2,2,4,4-tetramethylchroman-6-carboxylate (Compound 29, 1.36 g, 4.73 mmol) in ethanol (14 mL) was treated with 3N aqueous sodium hydroxide solution (3 mL, 15 mmol) and was stirred at ambient temperature for 3 h. The resulting solution was adjusted to pH˜5 with 10% aqueous hydrochloric acid and extracted with ethyl acetate. The organic phase was dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to afford the title product as a white solid (1.15 g, 94%).

Provenance & Evidence