Formic Acid → HCID 10287701, compound

Participants

Reaction Steps

A solution of 8-cyano-2,2,4,4-tetramethyl chroman-6-carboxylic acid-3-fluoro-4-tert-butoxycarbonylmethyl-phenyl ester (Compound 31, 0.084 g, 0.18 mmol) in 1,4-dioxane (4 mL) and THF (2 mL) was treated with formic acid (15 mL) at ambient temperature. After 2 h, the reaction mixture was diluted with water and extracted with diethyl ether. The organic phase was dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to afford the title product (0.055 g, 74%).

Provenance & Evidence