Aluminium lithium hydride → HCID 21919289, compound

Participants

Reaction Conditions

Reaction Steps

LiAlH4 (1N solution in THF, 1 mL) is added to a stirred solution of 4,6-diethoxy-pyridazine-3-carboxylic acid ethyl ester (213 mg, 0.8 mmol) in THF (8 mL), cooled to 0° C. The solution is stirred at 0° C. for 3 hours. Excess Na2SO4.10H2O is then added and the mixture is stirred at room temperature for 45 minutes. The solid is filtered and washed with EtOAc. Evaporation of the filtrate in vacuo provides a light yellow oil. This alcohol used in the next step without further purification. LC-MS (M+1) 199.2.

Provenance & Evidence