Water → Perindopril erbumine monohydrate

HRID 898741Notes

Reaction equation

HRID 898741 reaction equation
[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:27][C:28]([NH2:31])([CH3:30])[CH3:29].[OH2:32]>CC(C)=O>[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:27][C:28]([NH2:31])([CH3:30])[CH3:29].[OH2:32]

Participants

4

Reactant 2

HCID 962WaterHCID 441313Perindopril Erbumine

Product 1

HCID 9847044Perindopril erbumine monohydrate

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Perindopril erbumine (10 gms) was suspended in acetone (80 ml). To this was added water (0.4 ml) and the contents heated to dissolve the solids and cooled to ambient. The resulting slurry was filtered to obtain perindopril erbumine monohydrate (9.4 gms).

Workup

  1. temperaturethe contents heated
  2. dissolutionto dissolve the solids
  3. temperaturecooled
  4. filtrationThe resulting slurry was filtered

Sources & evidence

ORD record
ord-274ca6923c744e3db9f70350da48dd55
Source dataset
uspto-grants-2008_04
Patent number
US07351840B2

Reaction notes

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