Benzylamine → HCID 11268889, compound

HRID 898789Notes

Reaction equation

HRID 898789 reaction equation
[O:1]1[CH2:3][CH:2]1[CH2:4][N:5]([CH2:15][CH:16]1[CH2:18][O:17]1)[S:6]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:8])=[O:7].[CH2:19]([NH2:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C(O)C>[CH2:19]([N:26]1[CH2:3][CH:2]([OH:1])[CH2:4][N:5]([S:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)(=[O:8])=[O:7])[CH2:15][CH:16]([OH:17])[CH2:18]1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 11207928N,N-bis(2-oxiranylmethyl)benzenesulfonamide

Product 1

HCID 11268889HCID 11268889, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The crude product from step (i) above was dissolved in ethanol (200 mL) and treated at room temperature with benzylamine (6.9 mL, 1 equiv.) in one portion (no exotherm was observed). The mixture was heated to reflux for 4 hours, and was then stirred at ambient temperature overnight. The solvent was removed in vacuo to give a viscous, colourless oil which was used in the subsequent step without further purification.

Workup

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 4 hours
  3. customThe solvent was removed in vacuo
  4. customto give a viscous, colourless oil which
  5. customwas used in the subsequent step without further purification

Sources & evidence

ORD record
ord-c7771b28f8664c00bbbe91c7ae93e2e0
Source dataset
uspto-grants-2008_04
Patent number
US07351821B2

Reaction notes

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