2,3-Dimethyl-2-phenyloxirane → HCID 67524986, compound

Temperature

60 °C

To a solution of trans-2,3-dimethyl-2-phenyloxirane (14 g, 76 mmol) in methanol (100 mL) was added 15% aqueous sodium methyl mercaptan solution (61 mL, 190 mmol) under nitrogen atmosphere at room temperature, and the mixture was warmed to 60° C. and stirred for 2 hours. The mixture was concentrated under reduced pressure, and the residue was extracted twice with diethyl ether (50 mL), sequentially washed with water (50 ml) and saturated aqueous sodium chloride solution (50 mL), and dried over sodium sulfate. The resultant mixture was filtrated and the solvent was evaporated to give the title compound (16 g, yield 99%) as a colorless oil.

1. concentrationThe mixture was concentrated under reduced pressure
2. extractionthe residue was extracted twice with diethyl ether (50 mL)
3. washsequentially washed with water (50 ml) and saturated aqueous sodium chloride solution (50 mL)
4. dry with materialdried over sodium sulfate
5. filtrationThe resultant mixture was filtrated
6. customthe solvent was evaporated

ORD record

ord-770047fb126646ac98526d685cb8f5f5

Source dataset

uspto-grants-2008_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07351825B2