反应详情

温度

-40 °C

While cooling to −40° C., sulfuryl chloride (2.9 mL, 37 mmol) was added dropwise to a solution of dimethyl disulfide (3.3 mL, 37 mmol) in 1,2-dimethoxyethane (20 mL) under nitrogen atmosphere, and the mixture was stirred for 10 min. The obtained solution was added dropwise to a solution of 4-fluoro-α-methylstyrene (10 g, 73 mmol) in 1,2-dimethoxyethane (20 mL) while maintaining a temperature below −30° C. After stirring for 1 hour at room temperature, the solution was evaporated to give a crude product of the title compound. The obtained product was used in the next step without further purification.

1. temperaturewhile maintaining a temperature below −30° C
2. stirringAfter stirring for 1 hour at room temperature
3. customthe solution was evaporated