p-(Trifluoromethoxy)phenyl isocyanate → HCID 68812777, compound

HRID 898877Notes

Reaction equation

HRID 898877 reaction equation
[C:1]([O:5][C:6](=[O:23])[C:7]([S:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[CH2:16][CH:15]([NH:20][CH2:21][CH3:22])[CH2:14]2)([CH3:9])[CH3:8])([CH3:4])([CH3:3])[CH3:2].[F:24][C:25]([F:37])([F:36])[O:26][C:27]1[CH:32]=[CH:31][C:30]([N:33]=[C:34]=[O:35])=[CH:29][CH:28]=1>C(Cl)Cl>[C:1]([O:5][C:6](=[O:23])[C:7]([S:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[CH2:16][CH:15]([N:20]([CH2:21][CH3:22])[C:34]([NH:33][C:30]1[CH:31]=[CH:32][C:27]([O:26][C:25]([F:24])([F:36])[F:37])=[CH:28][CH:29]=1)=[O:35])[CH2:14]2)([CH3:9])[CH3:8])([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 2

HCID 92298p-(Trifluoromethoxy)phenyl isocyanateHCID 11631393HCID 11631393, compound

Product 1

HCID 68812777HCID 68812777, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a mixture of 2-(2-ethylaminoindan-5-ylsulfanyl)-2-methylpropionic acid tert-butyl ester and borane complex (11.0 g; 33 mmol), dissolved in CH2Cl2 (100 mL), is added 4-trifluoromethoxyphenyl isocyanate (10.2 g; 50.2 mmol) and the reaction was allowed to stir at RT for 18 h. The solvent was removed under reduced pressure and the crude residue was purified by flash chromatography (SiO2) eluting with a hexanes-EtOAc gradient to afford 11.2 g (62%) of 2-{2-[1-ethyl-3-(4-trifluoromethoxyphenyl)ureido]indan-5-ylsulfanyl}-2-methylpropionic acid tert butyl ester as a white foam.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude residue was purified by flash chromatography (SiO2)
  3. washeluting with a hexanes-EtOAc gradient

Sources & evidence

ORD record
ord-2bcca9339c6c41de9632431c9896815f
Source dataset
uspto-grants-2008_04
Patent number
US07351857B2

Reaction notes

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