4-Acetoxyindole → Acetic Acid 3-(dimethylaminophenylmethyl)-1H-indol-4-yl Ester

HRID 8989Notes

Reaction equation

HRID 8989 reaction equation
[NH:1]1[C:9]2[C:4](=[C:5]([O:10][C:11](=[O:13])[CH3:12])[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[Cl-].[CH:15](=[N+:22]([CH3:24])[CH3:23])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH3:23][N:22]([CH:15]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][C:5]=2[O:10][C:11](=[O:13])[CH3:12])[NH:1][CH:2]=1)[CH3:24]

Participants

3

Reactant 2

HCID 5839344-AcetoxyindoleHCID 11073839Methanaminium, N-methyl-N-(phenylmethylene)-, chloride

Product 1

HCID 23549120Acetic Acid 3-(dimethylaminophenylmethyl)-1H-indol-4-yl Ester

Procedure

The preparation was carried out in accordance with general synthesis instructions 4 from acetic acid 1H-indol-4-yl ester and benzylidene-dimethyl-ammonium chloride, which had been prepared in accordance with example 1.

Workup

  1. customhad been prepared in accordance with example 1

Sources & evidence

ORD record
ord-84e9a07ef0414834be82c2870362ad02
Source dataset
uspto-grants-2006_08
Patent number
US07091220B2

Reaction notes

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