反应详情

A mixture of 4-(3-methoxycarbonyl-4-methoxyphenoxy)-1-nitrobenzene (1.2 g), KOH (0.33 g) and water (5 mL) in MeOH (45 mL) was stirred at room temp. overnight and then heated at the reflux temp. for 4 h. The resulting mixture was cooled to room temp. and concentrated under reduced pressure. The residue was dissolved in water (50 mL), and the aqueous mixture was made acidic with a 1N HCl solution. The resulting mixture was extracted with EtOAc (50 mL). The organic layer was dried (MgSO4) and concentrated under reduced pressure to give 4-(3-carboxy-4-methoxyphenoxy)-1-nitrobenzene (1.04 g).

1. temperatureheated at the reflux temp
2. waitfor 4 h
3. temperatureThe resulting mixture was cooled to room temp.
4. concentrationconcentrated under reduced pressure
5. dissolutionThe residue was dissolved in water (50 mL)
6. extractionThe resulting mixture was extracted with EtOAc (50 mL)
7. dry with materialThe organic layer was dried (MgSO4)
8. concentrationconcentrated under reduced pressure