反应详情

A solution of 2-(6-Amino-pyridin-3-ylmethyl)-N-benzyl-N-benzyloxy-succinamic acid (0.9 g, 1.7 mmol) and palladium (0.5 g, 5% on charcoal) in methanol (100 mL) was hydrogenated at 1 bar for 2 h. The reaction mixture was filtered and concentrated under reduced pressure. The residue was purified by flash chromatography (CHCl3/MeOH/H2O, 10:5:1) to give the title compound (123 mg, 22%).

1. filtrationThe reaction mixture was filtered
2. concentrationconcentrated under reduced pressure
3. customThe residue was purified by flash chromatography (CHCl3/MeOH/H2O, 10:5:1)