HCID 69292291, compound → HCID 69289294, compound

HRID 899106Notes

Reaction equation

HRID 899106 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][O:11][CH:10]([C:14]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)([OH:24])CC2C(F)=CC=CC=2Cl)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:31][O:32][C:33]1[CH:41]=[CH:40][C:39]([O:42][CH3:43])=[CH:38][C:34]=1[CH2:35][Mg]Cl>>[CH2:1]([N:8]1[CH2:13][CH2:12][O:11][CH:10]([C:14]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)([OH:24])[CH2:35][C:34]2[CH:38]=[C:39]([O:42][CH3:43])[CH:40]=[CH:41][C:33]=2[O:32][CH3:31])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 69292291HCID 69292291, compoundHCID 178492581HCID 178492581, compound

Product 1

HCID 69289294HCID 69289294, compound

Procedure

The procedure for the synthesis of example 18a, 1-(4-Benzyl-morpholin-2-yl)-2-(2-chloro-6-fluoro-phenyl)-1-phenyl-ethanol, using 2,5-dimethoxybenzyl magnesium chloride as starting material (available from Rieke Metals) was followed making non-critical variations, to yield the title compound. This material was used in step b) without further purification. LCMS (6 minutes method) [M+H]+=434 @ Rt 3.10 min. major peak.

Sources & evidence

ORD record
ord-2da56056fdcd4a538c30bf5f4f9bad87
Source dataset
uspto-grants-2008_04
Patent number
US07354920B2

Reaction notes

Loading…