HCID 69292291, compound → HCID 69291610, compound

HRID 899108Notes

Reaction equation

HRID 899108 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][O:11][CH:10]([C:14]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)([OH:24])[CH2:15][C:16]2[C:21](F)=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:23])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:31]C1C=CC=C(Cl)C=1C[Mg]Cl>>[CH2:1]([N:8]1[CH2:13][CH2:12][O:11][CH:10]([C:14]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)([OH:24])[CH2:15][C:16]2[C:21]([Cl:31])=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:23])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 69292291HCID 69292291, compoundHCID 178479001HCID 178479001, compound

Product 1

HCID 69291610HCID 69291610, compound

Procedure

The procedure for the synthesis of example 18a, 1-(4-Benzyl-morpholin-2-yl)-2-(2-chloro-6-fluoro-phenyl)-1-phenyl-ethanol, using 2,6-dichlorobenzyl magnesium chloride as starting material (available from Rieke Metals) was followed making non-critical variations, to yield the title compound. This material was used in step b) without further purification. LCMS (6 minutes method) [M+H]+=442 @ Rt 3.49 min. major peak.

Sources & evidence

ORD record
ord-98d344c4bf9040aeb93615c1dd02b5c8
Source dataset
uspto-grants-2008_04
Patent number
US07354920B2

Reaction notes

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