反应详情

温度

120 °C

4-(2-Bromoethoxy)benzonitrile (30 g, 0.133 mol; see step (i) above) and ethanolamine (48 mL, 0.78 mol) were mixed and refluxed, under a nitrogen atmosphere, at about 120° C. for 3 h. The reaction was quenched by addition of a sodium hydroxide solution to the mixture. The sub-title compound was extracted using DCM (2×250 mL), which was dried over anhydrous sodium sulfate and then concentrated. Yield: 13.1 g (48%).

1. customThe reaction was quenched by addition of a sodium hydroxide solution to the mixture
2. extractionThe sub-title compound was extracted
3. dry with materialwas dried over anhydrous sodium sulfate
4. concentrationconcentrated