反应详情

7-(2-{1-[2-(4-Cyanophenoxy)ethyl]-3,3-dimethylureido}ethyl)-9-oxa-3,7-di-azabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester (6.5 g; see Example 5 below) was taken in HCl in dioxane (50 mL) and stirred for 30 min. The reaction mixture was decanted and the solid was taken in a biphasic mixture of dichloromethane and aqueous NaHCO3. The organic layer was separated, washed with water, dried over sodium sulfate and concentrated. Purification by column chromatography yielded 1.3 g of the title compound as pale yellow solid.

1. customThe reaction mixture was decanted
2. additionthe solid was taken in a biphasic mixture of dichloromethane and aqueous NaHCO3
3. customThe organic layer was separated
4. washwashed with water
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated
7. customPurification by column chromatography