HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 899131Generated: October 29, 2026
N,N'-Dimethylurea → 1-[2-(4-Cyanophenoxy)ethyl]-1-(2-hydroxyethyl)-3-methylurea
https://huagongshe.com/reaction/899131
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N,N'-Dimethylurea | HCID 7293 | — |
| Reactant | 4-{2-[(2-Hydroxyethyl)amino]ethoxy}benzonitrile | HCID 69068625 | — |
| Product | 1-[2-(4-Cyanophenoxy)ethyl]-1-(2-hydroxyethyl)-3-methylurea | HCID 69072079 | 54.3% |
Reaction Steps
4-[2-(2-Hydroxyethylamino)ethoxy]benzonitrile (1 g, 0.009 mol; see Preparation C, step (ii) above) and N,N′-dimethylurea (0.43 g, 0.0049 mol) were heated with stirring at 130° C. for 4 h. The reaction was directly purified by column chromatography to yield 0.7 g of the sub-title product as an off white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07354917B2 |
|---|
| Source dataset | uspto-grants-2008_04 |
|---|
| ORD ID | ord-3fcf4dca27f5419886967d6770579a05 |
|---|
| Source note | uspto-grants-2008_04 |
|---|
