Potassium Carbonate → HCID 11526582, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 4-[3-(9-oxa-3,7-diaza-bicyclo[3.3.1]non-3-yl)-propoxy]-benzonitrile (1.5 g, 5.5 mmol, see WO 01/28992), methanesulfonic acid 2-[methanesulfonyl-(2-phenoxy-ethyl)-amino]-ethyl ester (1.51 g, 4.5 mmol, preparation P above) and dry K2CO3 (1.69 g, 12.3 mmol) in dry acetonitrile (100 ml) was stirred at 60° C. overnight under nitrogen atmosphere. The reaction mixture was filtered and solvent concentrated under reduced pressure. The residue was purified by column chromatography over silica gel using 3% methanol in dichloromethane as eluent to give the title compound (1.4 g) as a liquid.

Provenance & Evidence