4-(Trifluoromethyl)phenylboronic acid → HCID 135446024, compound

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Reaction Steps

This compound was prepared from 7-bromo-3,9-dihydroxy-6H-chromeno[4,3-b]quinoline (7) using 4-trifluoromethylphenylboronic acid according to method M. Yellow powder; Yield: 95%; mp 175-177° C. (dec.); 1H-NMR (400 MHz, DMSOd-6) δ 5.00 (s, 2H), 6.36 (d, J=2.3 Hz, 1H), 6.56 (d, J=2.6 Hz, 1H), 6.61 (dd, J=8.6, 2.2 Hz, 1H), 7.26 (dd, J=9.1, 2.6 Hz, 1H), 7.64 (d, J=7.9 Hz, 2H), 7.92 (d, J=9.0 Hz, 1H), 7.98 (d, J=8.1 Hz, 2H), 8.16 (d, J=8.6 Hz, 1H), 9.84 (s, 1H), 10.00 (s, 1H); 19F-NMR (400 MHz, DMSOd-6) δ −61.43 (s); MS (ESI) m/z 408 ([M−H]−), 410 ([M+H]+); HRMS (ESI+) calcd for C23H14F3NO3 410.0999 ([M+H]+). Found: 410.0992.

Provenance & Evidence