反应详情

A solution of 50 mg (0.13 mmol) of ((3R)-N-(4′-aminobiphenyl-4-yl)quinuclidine-3-carboxamide dihydrochloride (Example 7A) and 44.4 mg (0.25 mmol) of 3-chlorobenzoyl chloride in 1.0 ml of pyridine is stirred at room temperature for 3 h. The reaction mixture is concentrated in vacuo, and the residue is purified by preparative HPLC. The product fractions are concentrated, mixed with 3 ml of 1 N hydrochloric acid, again concentrated and dried under high vacuum. 62 mg (98.5% of theory) of the title compound are obtained.

1. concentrationThe reaction mixture is concentrated in vacuo
2. customthe residue is purified by preparative HPLC
3. concentrationThe product fractions are concentrated
4. additionmixed with 3 ml of 1 N hydrochloric acid
5. concentrationagain concentrated
6. customdried under high vacuum