(4-Bromophenyl)boronic acid → HCID 11476619, compound

HRID 899225Notes

Reaction equation

HRID 899225 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[N:10]([CH3:11])[C:9](=[O:12])[O:8][C:7]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)([CH3:13])[C:6]=2[CH:21]=1.[Br:22][C:23]1[CH:28]=[CH:27][C:26](B(O)O)=[CH:25][CH:24]=1>>[Br:22][C:23]1[CH:28]=[CH:27][C:26]([NH:1][C:2]2[CH:3]=[CH:4][C:5]3[N:10]([CH3:11])[C:9](=[O:12])[O:8][C:7]([C:14]4[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=4)([CH3:13])[C:6]=3[CH:21]=2)=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 79599(4-Bromophenyl)boronic acidHCID 69212235HCID 69212235, compound

Product 1

HCID 11476619HCID 11476619, compound

Procedure

Prepared from 6-amino-4-(4-chlorophenyl)-1,4-dimethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one and 4-bromophenyl boronic acid according to the coupling procedure described in example 1. MS (ESI) m/z [M+H]+(457/459/461); MS (ESI) m/z [M−H]−(455/457/459); Anal. calcd for C22H18BrClN2O2: C, 57.73; H, 3.96; N, 6.12. Found: C, 56.88; H, 3.90; N, 5.70.

Sources & evidence

ORD record
ord-d8dcfc6dcdc942c99cd389eeaf253d27
Source dataset
uspto-grants-2008_04
Patent number
US07354915B2

Reaction notes

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