t-butyl hydroxymethylacrylate → HCID 69264412, compound

HRID 899262Notes

Reaction equation

HRID 899262 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:15][O:14][C:8]3([CH2:13][CH2:12][NH:11][CH2:10][CH2:9]3)[C:6]=2[CH:7]=1.[OH:16][CH2:17][C:18](=[CH2:26])[C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:15][O:14][C:8]3([CH2:9][CH2:10][N:11]([CH2:26][CH:18]([CH2:17][OH:16])[C:19]([O:21][C:22]([CH3:24])([CH3:23])[CH3:25])=[O:20])[CH2:12][CH2:13]3)[C:6]=2[CH:7]=1

Participants

3

Reactant 2

HCID 10329532t-butyl hydroxymethylacrylateHCID 10352977HCID 10352977, compound

Product 1

HCID 69264412HCID 69264412, compound

Procedure

The title compound was prepared according to the procedure described in step 4 of example 4 from 6-fluoro-3H-spiro[2-benzofuran-1,4′-piperidine] (J. Med. Chem. 1995, 38, 2009.) and tert-butyl 2-(hydroxymethyl)acrylate (Synlett 1997, 12, 1417.):

Sources & evidence

ORD record
ord-f1af659867fe46bfaa2822fa42bda9c9
Source dataset
uspto-grants-2008_04
Patent number
US07354925B2

Reaction notes

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