HCID 11696864, compound → HCID 86603162, compound

HRID 899346Notes

Reaction equation

HRID 899346 reaction equation
[C:1]([C@@H:4]([C@H:6]([C:8]([OH:10])=[O:9])[OH:7])[OH:5])([OH:3])=[O:2].[Cl:11][C:12]1[CH:13]=[C:14]([N:19]2[CH2:25][C@@H:24]3[C@@H:21]([CH2:22][NH:23]3)[CH2:20]2)[CH:15]=[N:16][C:17]=1[Cl:18]>O>[OH2:2].[C:1]([C@@H:4]([C@H:6]([C:8]([OH:10])=[O:9])[OH:7])[OH:5])([OH:3])=[O:2].[Cl:11][C:12]1[CH:13]=[C:14]([N:19]2[CH2:25][C@@H:24]3[C@@H:21]([CH2:22][NH:23]3)[CH2:20]2)[CH:15]=[N:16][C:17]=1[Cl:18]

Participants

3

Reactant 1

HCID 11696864HCID 11696864, compound

Product 1

HCID 86603162HCID 86603162, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
70 °C

Procedure

A solution of the product of Example 12 (100 mg) in water (2 mL) was obtained by sonicating for 30 seconds followed by heating to 70° C. This solution was cooled to room temperature and then cooled in a methanol/dry-ice bath. After solids crystallized the slurry was stirred at 30° C. and then the mixture filtered to provide a white solid.

Workup

  1. customby sonicating for 30 seconds
  2. temperatureThis solution was cooled to room temperature
  3. temperaturecooled in a methanol/dry-ice bath
  4. customAfter solids crystallized the slurry
  5. filtrationthe mixture filtered
  6. customto provide a white solid

Sources & evidence

ORD record
ord-ef40300078c245fdac8722ab14d496b7
Source dataset
uspto-grants-2008_04
Patent number
US07354937B2

Reaction notes

Loading…