Lithium Hydroxide → 2-(2,1,3-Benzoxadiazol-5-yloxy)nicotinic acid

Participants

Reaction Steps

A mixture of 2.2 g (7.7 mmol) 2-[benzo[2,1,3]oxadiazol-5-yloxy]-nicotinic acid ethyl ester and 23.1 ml (23.1 mmol) 1M LiOH in 75 ml tetrahydrofuran was stirred overnight at room temperature. The tetrahydrofuran was evaporated in vacuo and the aqueous mixture was then acidified with 1N HCl. The resulting precipitate was filtered and dried to give 1.9 g (96%) solid.

Provenance & Evidence