Ammonium Hydroxide → HCID 59104144, compound

Participants

Reaction Steps

A mixture of 0.63 g (0.54 mmol) Pd(PPh3)4 and 25.3 g (162 mmol) NDMBA was combined and placed under N2. Thereafter, a solution of 7.0 g (27 mmol) (R)-2-[4-(1-diallylamino-ethyl)-phenyl]-propan-2-ol in 140 ml CH2Cl2 was added. The resulting mixture was then refluxed under N2 for 2 hours. The crude reaction mixture was then loaded onto coarse silica gel. Chromatography on silica gel using 7.5% MeOH/CH2Cl2 followed by 2% NH4OH/ 10% MeOH/CH2Cl2 yielded 4.5 g (93%) of the desired product.

Provenance & Evidence