Hydrochloric Acid → 2-(Benzo[2,1,3]thiadiazol-5-yloxy)-nicotinic acid

Participants

Reaction Steps

A solution of 2-(benzo[2,1,3]thiadiazol-5-yloxy)-nicotinic acid ethyl ester (0.74 g, 2.5 mmol) in tetrahydrofuran (2.78 ml) and 1 M LiOH (2.7 ml) was stirred over night. The mixture was diluted with water and then acidified to pH 1 with 2 N hydrochloric acid, and thereafter filtered to give a pale yellow solid (160 mg).

Provenance & Evidence