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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 899409Generated: October 28, 2026

5-Bromo-2-fluorobenzaldehyde → 5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-amine

https://huagongshe.com/reaction/899409

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Bromo-2-fluorobenzaldehydeHCID 736327—
Reactant5-(3-Methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-amineHCID 178434271—
Product5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-amineHCID 67091741—

Reaction Steps

5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-amine was synthesized in a way similar to that of 4f as shown in Scheme 3 with commercially available 5-bromo-2-fluorobenzaldehyde as the starting material in three steps. MS (API-ES) m/z (%): 218 (100%, M++1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07354944B2
Source datasetuspto-grants-2008_04
ORD IDord-cece80de08784bbbaa21c363afd0962f
Source noteuspto-grants-2008_04