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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 899410Generated: October 28, 2026

Carbon Dioxide → HCID 23070103, compound

https://huagongshe.com/reaction/899410

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCarbon DioxideHCID 280—
Reactant5-Bromo-6-fluoro-1H-indazoleHCID 46863923—
ReactantHCID 178418306HCID 178418306—
ProductHCID 23070103HCID 23070103—

Reaction Steps

This compound was prepared in a manner similar to that shown in Scheme 3, using 5-bromo-6-fluoro-1H-indazole (88d), which was treated with t-butyl lithium and carbon dioxide to yield 6-fluoro-1H-indazole-5-carboxylic acid. This compound in turn was treateded with thiosemicarbazide and polyphosphoric acid to form 5-(6-fluoro-1H-indazol-5-yl)-1,3,4-thiadiazol-2-amine. MS (API-ES) m/z (%): 236 (100%, M++1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07354944B2
Source datasetuspto-grants-2008_04
ORD IDord-f438acaddceb49a6bbde02a873661fe9
Source noteuspto-grants-2008_04