Acetic Anhydride → HCID 178475126, compound

HRID 899418Notes

Reaction equation

HRID 899418 reaction equation
[CH3:1][C:2]1[C:10]2[C:5](=[N:6][CH:7]=[C:8]([CH:11]=[N:12][NH:13][C:14]([NH2:16])=[S:15])[CH:9]=2)[NH:4][N:3]=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>>[C:17]([NH:16][C:14](=[N:13]/[N:12]=[CH:11]/[C:8]1[CH:9]=[C:10]2[C:2]([CH3:1])=[N:3][NH:4][C:5]2=[N:6][CH:7]=1)[SH:15])(=[O:19])[CH3:18]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 178434443HCID 178434443, compound

Product 1

HCID 178475126HCID 178475126, compound

Conditions

Temperature
80 °C

Procedure

The staring material 1-((3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methylene)thiosemicarbazide (500 mg, 2.0 mmol) and acetic anhydride (20 ml) was mixed and heated to 80° C. for 1 hour. The reaction mixture was then cooled down to room temperature. The yellow solid was precipitated out and was filtered off. The yellow solid was washed with ether (50 ml). The product was obtained in quantitative yield and used for the next step without further purification.

Workup

  1. temperatureThe reaction mixture was then cooled down to room temperature
  2. customThe yellow solid was precipitated out and
  3. filtrationwas filtered off
  4. washThe yellow solid was washed with ether (50 ml)
  5. customThe product was obtained in quantitative yield
  6. customused for the next step without further purification

Sources & evidence

ORD record
ord-89f23f75c9004a259fc5c6b7252ec4b2
Source dataset
uspto-grants-2008_04
Patent number
US07354944B2

Reaction notes

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