Hydrochloric Acid → 3,6,9,12,15,18,21-Heptaoxatricosanoic acid, 23,23,23-trifluoro-

Participants

Reaction Steps

The product of step (e) (400 mg) was dissolved in an aqueous sodium hydroxide solution (0.1M) (10 ml) and the reaction was stirred at room temperature for 16 hours. The reaction mixture was acidified to pH 2 by the addition of hydrochloric acid (2M), then this was diluted with brine (200 ml) and extracted with dichloromethane (2×200 ml). The combined organic layers were dried and the solvent removed in vacuo to give the title compound as a colourless oil (330 mg).

Provenance & Evidence